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Furthermore, fasting induces a metabolic shift from glucose to ketone utilization, providing neurons with a potent energy source that reduces mitochondrial stress and enhances bioenergetic stability [76]

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In fact, the very first drug approved for the treatment of AUD was disulfiram, a drug that inhibits ALDH2 and, therefore, capitalizes on the resultant aversive effects of acetaldehyde accumulation after alcohol intake (308)

Moreover, it is evident that genetic polymorphisms in these enzymes are responsible for the developement of a number of neurological disorders or cancers

Co-depletion of Esco1/2 by siRNA induced similar levels of cohesion loss in CB-GFP and CB-Sororin-CTR-GFP cells (~23.3% and ~20.5%, respectively) (Fig