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When the tissue is damaged, tissue proteases break down SPARC, releasing an array of GHK and GHK-containing copper-binding peptides, which stimulate cell proliferation and new vessels growth

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While the N-terminal proteins were unstable, both the ENST00000374259.8 and the N-terminal deletion variant of FOXO4 lost the ability to transactivate the FOXO4 target gene, BCL6 in a dominant-negative manner