Thank you to our sponsors AG1 (Athletic Greens): Thesis: InsideTracker: Helix Sleep: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Assessing Health Status & Improving Vitality (00:02:51) Momentous Supplements (00:03:46) Thesis, InsideTracker, Helix Sleep (00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The 4 Horseman of Disease (00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States (00:13:59) Blood Testing: Best Frequency (00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis (00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids (00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training (00:31:03) AG1 (Athletic Greens) (00:32:16) Back-casting: Defining Your Marginal Decade (00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max (00:44:43) Attias Rule of Supplementation, Centenarian Decathlete Physical Goals (00:49:24) Importance of Exercise, Brain Health, MET hours (00:55:23) Nicotine & Cognitive Focus (01:03:12) Menstruation, PMS & Menopause (01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk (01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women (01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin (01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG (01:47:46) Fadogia Agrestis, Supplements, Rapamycin (01:52:06) Testosterone Replacement Therapy & Fertility (01:59:26) Total Testosterone vs

But none of this shows visibly yet
PCs treatment reduced MFG-E8, phospho-ERK1/2, phospho-Akt, and phospho-GSK-3 levels in db/db mouse kidneys, indicating MFG-E8s influence on the progression of diabetic nephropathy
PMID: 42297062 Oncol Rep Schisandrin B exhibits antiproliferative effects by inducing ferroptosis in pancreatic cancer
Brain Res 902:156163 Chen Y, Swanson RA (2003) The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures
Clinical studies tested doses ranging from 250mcg to 1mg daily, with 300mcg showing effective fat reduction at the lowest side effect profile