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This is supported by reductions in neuroinflammatory mediators, including TNF-, IL-1, and iNOS, alongside the downregulation of TLR4 transcriptional regulators, such as p-c-Jun and PU.1 [171]

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10.1002/smll.202106172 76 LuY.ChenZ.LinQ.XiaX.LinY.YanJ.et al (2023)

[6] The reaction mechanism of the P-450 oxidases proceeds through the reduction of cytochrome-bound oxygen and the generation of a highly-reactive oxyferryl species, according to the following scheme: [7] Phase II - conjugation [edit] In subsequent phase II reactions, these activated xenobiotic metabolites are conjugated with charged species such as glutathione (GSH), sulfate, glycine, or glucuronic acid