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2,4-D Herbicide-induced hepatotoxicity: unveiling disrupted liver functions and associated biomarkers

10.1016/j.lanwpc.2023.100955 107 XieD.LiuG.ZhuG.WuW.GeS

Both of these direct oxidation processes affect crucial active site cysteine residues and result in a loss of enzymatic activity (Halloran et al., 2013)

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For people with genetic variants that cause more of an impact on CYP1B1 upregulation combined with an inability to eliminate the estrogen metabolites fast enough (due to phase II genes, diet, and lifestyle) then cigarette smoking is going to significantly increase the bad estrogen metabolites