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For patients with Brugada syndrome, Quinidine is an alternative to implantable cardioverter-defibrillator (ICD) placement (66) This class has also shown utility in individuals with short QT syndrome experiencing recurrent ventricular arrhythmias (VAs), reducing the frequency of ICD shocks in these patients (66)

In the brain of WT animals treated with vB12 versus PBS, we found 1831 DEGs (Figs 5A and S4C, Table S2), and in Tbx1 +/ animals treated with vB12 versus PBS, we found 1,639 DEGs (Figs 5A and S4B, Table S2)

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Also, treatment with Vardenafil has been shown to decrease DNA damage and oxidative stress, as well as to increase cGMP levels in aortic walls [24]