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Description

Glutaminase inhibitor CB-839 is now under clinical trials to evaluate safety and efficacy in combination with other anticancer drugs in cancers (Table 1)

10.1007/s10439-009-9892-x 8 AngeleP.YooJ

Inhibitory actions of opiates and synthetic opioids on secretomotor neurons and cholinergic neurotransmission in the ENS account for much of their constipating action

This review highlights established and emerging concepts, unanswered questions, and future challenges for development and optimization of GLP-1R agonists in the treatment of metabolic disease.