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Elevated levels of TNF-, IL-1, IL-1, and IL-6 are consistently reported, and these cytokines directly downregulate endothelial tight junction proteinsincluding claudin-5, occludin, and ZO-1thereby weakening barrier integrity and increasing paracellular permeability (Figure 1B

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Our group checked out the self-assembly of a PA designed based on the amyloid- peptide (C16-KKFFVLK) 50,51 (Fig 7)