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The functions of SCFAs are involved in modulating energy metabolism, regulating immune and inflammatory responses, and inhibiting oxidative stress and mitochondrial damage, which are mainly achieved through the activation of transmembrane G protein-coupled receptors (GPRs) and the inhibition of histone acetylation (HDAC) (7)

Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway

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However, with few clinical trials, it requires consistent, long-term use to achieve and sustain results

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