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The disadvantages of intravenous injections Unsuitable for slow absorption Time: the patient must remain lying down or seated for 30 min Risk of haematoma Must be administered by a qualified professional to prevent complications due to incorrect handling: gas embolism, blood backflow Intravenous injections are the most commonly-used method of administration when rapid results are required as they act directly on the bloodstream: as such, the substance is assimilated by the body almost instantly

doi: 10.1016/j.lwt.2020.110259

The advantage of using circulating blood cells, such as leukocytes, PBMC and erythrocytes, is their availability in routine clinical visits

Targeting these molecules with neutralizing antibodies or small-molecule antagonists (e.g., glycyrrhizin) has demonstrated BBB-stabilizing effects in vivo , including reductions in brain edema and vascular permeability (Lochhead et al., 2020

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