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The results showed that high maternal caffeine intake during pregnancy was associated with higher childhood general body fat mass, abdominal fat mass, and liver fat fraction at the age of 10 years, while differential fat accumulation in these depots may increase susceptibility to cardio-metabolic disease in later life ( FIGURE 4 According to the World Health Organization (WHO), epidemiological evidence indicates that in pregnant women, a caffeine intake of 300 mg/day (5 mg/kg day) is associated with an increased risk of intrauterine growth retardation (IUGR) ( via impacting histone acetylation and cholesterol synthesis-related gene expression via regulation of the A2AR/cAMP/PKA pathway and SIRT1 expression at the cellular level ( 3 Discussion The present study examined the beneficial use of caffeine in different liver diseases and its toxity