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Since human B lymphoma cells can bind via their 41 integrin to murine VCAM-1 molecules [16, 17], HGF induced adhesion of human c-MET-positive B cells to fibronectin probably via the activation of 41 integrin [15]

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Finally, the prepared system for each receptor-ligand complex was allowed for 100 ns MD simulation under default parameters using OPLS-2005 force field with the normal temperature (300 K) and pressure (1 bar), and a total of 10,000 frames were accumulated at successive 10 ps interval with molecular dynamics tool in the free academic Desmond module with Maestro-Schrdinger suite 2018-4 interface

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