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The interactions between these compounds are not well-understood and could lead to unforeseen consequences

To exert a bacteriostatic effect, the metabolites bind to bacterial ribosomes and stop protein synthesis in addition to inhibiting enzymes involved in the citric acid cycle and those in charge of DNA and RNA synthesis

doi: 10.1016/J.JAAD.2021.02.048 6

495 However, DHODH inhibition in SOD2-depleted cells reduced oxidative stress, lipid peroxidation, and ferroptosis, improving survival and colony formation, suggesting that DHODH activity sustains radiation-induced ferroptosis

A., Kushner, I

PARPs (poly(ADP-ribose) polymerases) use large amounts of cellular NAD+ during DNA damage repair