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Impact of Folate Deficiency on the Methionine Cycle A deficiency in folate disrupts this cycle, leading to metabolic imbalances, impaired methylation reactions, and downstream cellular dysfunctions

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Combined 13-Week Repeated Dose Toxicity Study With the Reproduction/Developmental Toxicity Screening Test by Oral Route (Dietary Admixture) in Rats

doi: 10.18632/aging.202936 70 TangH.ZhangS.TianY.KangT.ZhouC.YangS.et al

The amount of HGF inhibitor that is administered may be in the range of from about 0.1 to about 1,000 mg/kg, an preferably in the range of from about 1 to about 100 mg/kg, although as one of skill in the art will recognize, the precise amount may vary depending on one or more attributes of the drug recipient, including but not limited to: weight, overall health, gender, age, nationality, genetic history, other conditions being treated, etc., and larger or smaller doses are within the practice of this invention

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