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10.1046/j.1471-4159.1996.66041448.x 50

Figueredo FG, Lima LF, Morais-Braga MFB et al (2016) Cytoprotective effect of Lygodium venustum Sw

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The HFI series of compounds, e.g., 37 (HFI 419) identified in 2008 after the virtual screening are much more drug-like than the hexapeptides 11 (AL-11), 12 (IVDE77), and the potent macrocyclic Ang IV analogue 23 (HA08) and can hopefully after further systematic optimization be converted into bioactive small molecules with capacity to cross the blood-brain barrier

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the resultant APC, APR, exhibited enhanced degradation activity in breast cancer cells, albeit with the constraint of modest drug loading inherent to direct conjugation [234]