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doi: 10.2169/internalmedicine.46.0221 Summary Keywords alpha lipoic acid, chronic sleep deprivation, metabolic function, antioxidant, anti-inflammatory activity Citation Chang H-M, Lin H-C, Renn T-Y, Liu Y-C, Yen K-J, Liao C-K, Tikhonova MA, Amstislavskaya TG, Singh SK and Chen L-Y (2026) Manifold hepatoprotective actions of -lipoic acid on metabolic function through redox regulation, inflammatory modulation, and anti-apoptosis after chronic sleep-deprived injury
Dietary sources of ALA While ALA supplements provide concentrated doses, certain foods naturally contain ALA, albeit in smaller amounts.54 Incorporating these into your diet can support overall antioxidant intake: Organ meats: Kidney, heart, and liver are among the richest natural sources of ALA
COX-derived reactive species and transcriptional activity of interleukin-1beta ( IL-1 ), interleukin-6 ( IL-6 ), tumor necrosis factor- ( TNF- ), cyclooxygenase-2 ( COX-2 ), and inducible nitric oxide synthase ( iNOS ) are increased during aging (Michaud et al., 2013
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