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10.1111/j.1365-2958.1993.tb01727.x Mol

Some of the negative effects of high homocysteine levels are modulated by the PON1 genotype.[ref] BLMH and BPHL are additional enzymes that can also metabolize homocysteine-thiolactone.[ref] Higher levels of homocysteine-thiolactone are also found in chronic inflammatory conditions, such as rheumatoid arthritis, inflammatory eye disease, and AMD.[ref][ref][ref] Lets take a look at why high homocysteine levels cause problems in the body, and then well look at genetic variants in the above cycles that can affect homocysteine levels when combined with dietary choices

Pejovic, M., Stankovic, A

Sahoo et al., 2008c

Though the clinical manifestation varies greatly from person to person, it is typified by polycystic ovarian morphology, hyperandrogenism, and ovulatory malfunction

Comp Biochem Physiol Part C 133:435442 Stephensen E, Svavarsson J, Sturve J, Ericson G, Adolfsson-Erici M, Frlin L (2000) Biochemical indicators of pollution exposure in shorthorn sculpin ( Myoxocephalus scorpius ), caught in four harbours on the southwest coast of Iceland