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Freeman, PhD, explains that your mental health history factors into your risk: Women with a history of depression are nearly five times more likely to have a diagnosis of major depression in the menopausal transition, whereas women with no history of depression are two to four times more likely to report depressed mood compared with premenopausal women. Estrogen helps to support feel good brain chemicals, such as serotonin and norepinephrine, responsible for mood stabilization, alertness and energy

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