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This free iron undergoes the Fenton reaction, generating hydroxyl radicals (OH) that induce ferroptosis (17,18)

doi: 10.1038/ki.2014.270 106

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A complex network of defense and repair mechanisms counter these oxidation reactions (Masamba and Kappo, 2021), however, any difference between ROS production and safe detoxification indicates a metabolic state called oxidative stress which causes oxidative damage to the plant (Figure 1)

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A further rasch study confirms that ALSFRS-R does not conform to fundamental measurement requirements