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2.4 mg once weekly is the highest cagrilintide dose used in clinical development, including the CagriSema program

For many patients, evidence-based approaches such as cognitive behavioral therapy for insomnia, circadian rhythm support, medication review, sleep apnea screening, mental health treatment, and lifestyle changes may be more appropriate than experimental peptide therapy

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They found that DSIP can pass through this barrier in both directions, and the amount that gets through increases with higher concentrations of the peptide