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Seemingly in opposition to the theory that the diminished GH secretion of older age is a net detriment are observations that animal models of congenital GH deficiency have remarkably increased lifespan, and that humans with congenital GH deficiency may have decreased rates of age-related diseases such as diabetes and cancer

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The pivotal trials enrolled HIV patients with lipodystrophy-associated visceral fat accumulation

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Similarly, a lack of exercise can decrease blood flow and energy levels, impacting libido