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It is not known if tirzepatide will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people

Participants allocated to placebo groups are increasingly likely to withdraw from treatment or to adopt additional measures aimed at weight loss

Sep 2022;123(4):e199-e205

Amongst randomized patients who already lost 5% body weight during the 12-week intensive lifestyle lead-in period, subsequent treatment with ZEPBOUND resulted in a statistically significant reduction in body weight compared to placebo from randomization (Week 0) to Week 72