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Thus, our results suggest that activation of NRF2 might also be directly mediated by Mat1a deficiency, through the cooperation with CYP2E1

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found reduced oxidative stress in ASD children supplemented with Coenzyme Q10, and the supplementation also improved the childrens gastrointestinal problems and sleep disorders 35

Upregulation of the activity of Nrf2 and, subsequently, the antioxidant enzymes, could prevent the onset of DR complications in diabetic patients

Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3

Additionally, it was shown that P53, a significant gene in tumor suppression, has the ability to reduce SLC7A11 expression to inhibit cystine uptake by system x c , thereby impairing the activity of GPX4 and leading to decreased antioxidant capacity, ROS accumulation, and ferroptosis (47)