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Using local field potential (LFP) and visual evoked potential (VEP) recordings, it was discovered that Shank3-deficient mice exhibit impaired visual cortical gain control, manifesting as a limited dynamic response range to visual stimuli

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Left untreated, deficiency can lead to

This can cause some facial muscles to involuntarily contract along with other muscles, or tear ducts to become active during eating

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For the chronic dosing studies, most studies are looking at doses of 4 g/day.[ref] (This used to be the maximum recommended acetaminophen dose per day, but that has now changed to 3g/day.) For reference, a single over-the-counter Extra Strength Tylenol is 500 mg, with the directions saying not to exceed 6 tablets in 24 hours (so 3g/day)