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viverrini -related cholangiocarcinoma revealed differential mutational patterns, with frequent mutation of TP53 in the former (346)

doi: 10.1016/j.lfs.2021.119659 77 Mahul-MellierA

An additional efficacy measure, objective response rate, was also statistically different, with 41% of patients receiving Ogsiveo seeing a response versus just 8% of those on placebo

Results of the phase I clinical study of ND-L02-s0201 showed that intravenous administration of ND-L02-s0201 at a siRNA dose of 90 mg for 3 weeks was well-tolerated in healthy adults

This does not invalidate the findings but adds a potential source of bias Single-blind only: While the investigator assessing photos was blinded, patients knew whether they received the active serum or saline, which could influence self-reported satisfaction scores No long-term follow-up: The study ended at 6 months