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To identify the binding interface of the B-017 with BAX and the BAX/BNIP3, we performed photo-cross-linking with B-017 carrying a photo-reactive-p-benzoyl-L-phenylalanine (BpA) moiety at the C-terminus (B-017-BpA), followed by mass spectrometry (XL-MS) 41

This, in turn, is associated with side effects such as the appearance of dyskinesias

With age, GSH levels decrease by up to 50% compared to young subjects, contributing to increased oxidative stress and chronic low-grade inflammation (inflammaging). In the anti-ageing field, GSH IV acts on three main levels: direct neutralisation of free radicals and protection of dermal collagen, modulation of inflammation through NF-B inhibition, and reduction of melanogenesis through tyrosinase inhibition with clinically observable effects on skin tone and luminosity. The most robust clinical evidence concerns neuroprotection (improvement of motor symptoms in Parkinson's disease) and protection from chemotherapy-induced neuropathy

Treatment may include vestibular rehabilitation therapy and exposure training

doi: 10.1080/13813450701661198 89 FraternaleA.BrunduS.MagnaniM

BMC Evol Biol 8:39