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It's a transporter adaptation that compounds over consistent use

So, whilst there isnt any evidence that Glutathione (or its precursors) can make you hangover-proof theres certainly substantial cause to believe that it can reduce the severity and duration of a hangover

Recent meta-analysis indicates that the majority of studies (9 out of 11) report no significant circadian variation in total protein content while the few studies that do report variation may reflect false positive findings due to acrophase mismatch [3]

J Biol Chem 270 : 61196124

Effects of organic and inorganic selenium supplementation on selenoenzyme activity in blood lymphocytes, granulocytes, platelets and erythrocytes

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