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Circadian and Autonomic Measurements Animal studies examined body temperature, heart rate, blood pressure, stress responses and circadian timing

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Behavioral assessments focused on motor functions, specifically walking stride length analysis and forepaw rope hang time

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Dietary treatment Phe-reduced diet The harmful effect of Phe accumulation in blood and brain is best witnessed in untreated patients with PKU who develop irreversible neurological impairment and psychiatric symptoms if exposed to HPA [5]