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Moreover, using a truncated form of the PKD catalytic domain, it was shown that PKDs also regulate expression of proteins involved in glucose and lipid metabolism, -oxidation, and OXPHOS in C2C12 myotubes both in HDAC5-dependent and independent manner [175]

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Acknowledgements The authors express gratitude for the financial support provided by the Iran National Science Foundation (INSF) under project No.4004509, the Biotechnology Development Council of the Islamic Republic of Iran under grant No

RAR was the primary statistician for the study, and did the regression analysis

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