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[6] [25] At levels only slightly below normal, deficiency can result in fatigue, headaches, feeling faint, rapid breathing, pale skin, numbness or tingling, poor appetite, heartburn, poor balance, difficulty walking, poor reflexes, blurred vision, memory problems, depression, irritability, inattention, cognitive decline, dementia, and even psychosis

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Lentiviral knockdown of SIRT1 in PA-stimulated HepG2 cells abrogated the increase in p-AMPK/AMPK and the suppression of SREBP1 conferred by GADD45 overexpression (Fig