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One mediator of the orexigenic effect of ghrelin is AMP-activated protein kinase (AMPK), 76,77 a key enzyme regulator of energy homeostasis both peripherally and centrally

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Rockefeller scientists Bruce McEwen and Carla Nasca, in collaboration with Natalie Rasgon, psychiatry professor at the Stanford University School of Medicine, show that patients with a particular type of depression have decreased blood levels of the molecule acetyl-L-carnitine (LAC)a finding that may lead to improved diagnosis and treatment of major depressive disorder (MDD)