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Indeed, since the pituitary has a substantial DRD2 reserve for PRL inhibition, and PRL response reaches the plateau at about 40% receptor occupancy in rat pituitary cells ( Since FLNA is crucial for both DRD2 expression and signaling in lactotrophs, the loss of FLNA expression may be one of the mechanisms involved in loss of DA responsiveness previously documented in human prolactinomas

Mar 17 2018;10(3)doi:10.3390/nu10030368

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Apart from MG, glyoxalases can act on various other -oxoaldehydes produced in the living system, such as glyoxal and hydroxy-pyruvaldehyde 5

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10.1016/j.jaci.2016.05.011 8 BoucherR