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Gradual introduction : Start with lower doses and increase gradually to minimise gastrointestinal upset, particularly with berberine

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Isolation of glutathione conjugates, including a novel mixed glutathionylglucuronide conjugate, from the bile of rats treated intraperitoenally with pulegone led to the proposal that glutathione conjugation plays a major role in detoxication of the cytochrome P450-bioactivated pulegone metabolite (i.e