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Some researchers believe that GIP receptor activation partially offsets the nausea caused by GLP-1 stimulation, which could explain why some patients tolerate tirzepatide better than pure GLP-1 agonists despite receiving more potent appetite suppression

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doi:10.3233/JAD-2011-110503 Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T et al (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

The coronavirus disease 2019 (COVID-19) pandemic has further magnified this burden, as the viruss impact on the central nervous system (CNS) has been linked to mood disturbances, including depression and anxiety [4]

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