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As previously described 18 , NPs were characterized through dynamic light scattering (DLS) analysis in order to estimate their hydrodynamic diameter (D H )

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Furthermore, the cerebellar cortex of this group exhibited significant decreases in the mean Purkinje cells size and count and the granule cells count, as well as a significant increase in the mean glial cells count

This modulation led to a substantial increase in the elimination half-life of five active ingredientsmulberroside A, kukoamine B, ligiritin, liquiritin apioside, and GA ammonium saltcompared to their free forms (Fig