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doi: 10.1002/hep.27761

10.1001/jama.2014.11011 Arch

So, the raw materials and the hormetic stressors are the two key parts of the picture

Dopaminergic neurons in the SN are particularly sensitive to oxidative stress (Szirki et al., 1998) due to their elevated levels of pro-oxidant iron, which facilitates ROS production by reducing oxygen, and their low levels of glutathione, a crucial antioxidant in cellular metabolism (Sian-Hlsmann et al., 2011)