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Phase 2 study of canfosfamide in combination with pegylated liposomal doxorubicin in platinum and paclitaxel refractory or resistant epithelial ovarian cancer

Additionally, BIM, PUMA, and tBID can directly engage with BAX and BAK to initiate apoptosis [43, 44]

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Cancer stem-like cells often display elevated PD-L1 expression, which is transcriptionally regulated by mitochondrial stress responses and post-translationally modified via SIRT1-mediated deacetylation

These mechanisms affect synaptic plasticity, energy metabolism, and the integrity of the gutbrain barrier