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Ineffective erythropoiesis and its treatment

In mice, heterozygous mutation of Galntl5 impaired sperm motility, decreased the level of some glycolytic enzymes, disrupted protein loading to the acrosome, and induced aberrant localization of the ubiquitinproteasome machinery

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Cancer cells undergo metabolic reprogramming of lipids in the tumor niche

H 2 S causes vascular endothelial and smooth muscle cell hyperpolarization and vasorelaxation by activating K ATP channels through cysteine S-sulfhydration, which can enhance Kir6.1-PIP2 binding and reduce Kir6.1-ATP binding (19)