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however, adding a fourth mutation at K98 abolishes the promotion of ferroptosis

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With the known induction of GSTF genes by defense hormones or biotic stresses (Wagner et al., 2002), their known involvement in the synthesis of defense compounds as camalexin (Su et al., 2011), the peroxidase and GSH-conjugating HNE activities, it is conceivable that GSTF1 is involved in oxidative stress tolerance and/or oxidative signaling occurring in particular during pathogen or insect attacks