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One model for this rewriting of the epigenome is the presence of so-called memory domains where pioneer TF binding to nucleosomes in response to stimuli opens up chromatin in stress-responsive loci and allows epigenetic writers to remodel the chromatin to allow it to remain open after the stimuli are removed 32

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Code availability For the Shiny app and the omics analysis, the code is available at and References Tidball, J

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IGF-1 LR3 IGF-1 LR3 is a modified version of insulin-like growth factor-1 that has drawn significant attention for its connection to cellular growth and recovery pathways

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