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Banks et al

The 2.5 mg starting dose is not meant to be therapeutic on its own

Cell Mol Life Sci , 2014, 71(4): 683-697

In addition to its role in regulating seasonal physiology and influencing the circadian system and sleep patterns, melatonin is involved in cell protection, neuroprotection, and the reproductive system, among other possible functions

Unlike small-molecule drugs such as aspirin or ibuprofen, which can tolerate wide temperature swings without losing effectiveness, peptides are proteins with complex three-dimensional structures that depend on precise folding to function

Approaches such as One-Two Punch therapy, which combines senescence-inducing agents with senolytics, can significantly enhance treatment efficacy, reduce the risk of recurrence and resistance, and pave the way for more precise, personalized cancer therapies