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Therefore, simply recruiting polyubiquitin to the ATPase complex is not sufficient to initiate substrate processing

El Makawy et al

24 During choline deficiency, hepatic SAMe concentrations were also shown to decrease by as much as 50%

J Biol Chem 287(48):4051340524 Le Dour C, Macquart C, Sera F, Homma S, Bonne G, Morrow JP, Worman HJ, Muchir A (2017) Decreased WNT/-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene

doi: 10.1007/s12035-020-01988-1 251 RiadA.ZengC.WengC.-C.WintersH.XuK.MakvandiM.et al

Building on the descriptorimportance results, we next turn our attention to the underlying physicochemical property distributionsand how these raw profiles compare to the modeloptimized exemplars for each fragrance class (Fig