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ROS, whether directly or through the formation of lipid peroxidation products such as 4-hydroxy-2-nonanal, may play a role in enhancing inflammation by activating stress kinases (JNK, MAPK, p38) and redox-sensitive transcription factors such as NF-B and AP-1 (Rahman and MacNee, 2000)

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Once symptoms resolve, NAC can typically be restarted at a slower infusion rate without recurrence of adverse effects

doi: 10.3233/jad-150817 49 HouK.ZhaoJ.WangH.LiB.LiK.ShiX.et al

A 2014 study in JAMA found that about 40 percent of the largest publicly traded drug companies had a leader of an academic medical center on their boards