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Description

(Arrows denote activation

thus, any crucial alteration of protein structure/activity is fundamental to understanding how molecular events translate into clinical phenotypes

Our studies with the Broad Institutes Connectivity Map revealed its ability to regulate a large number of human genes including those that are involved in nervous system physiology, development, and maintenance

PMID: 29306952

The expression of mitochondrial marker Tom20 was reduced and the levels of mitophagy were increased in the HG-treated RECs, which was rescued by Drp1 silencing