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Facts : X linked recessive disorder, MC in AA men G6PD enzyme involved in creating NADPH (cofactor required to create glutathione and prevent oxidation of hemoglobin) Without G6PD, hemoglobin becomes oxidized and denatures into Heinz bodies Variants are G6PD A- (moderate enzyme deficiency) and G6PD Mediterranean (severe enzyme deficiency History / PE : Fever Jaundice Abdominal pain Hematuria Diagnosis : Heinz bodies (denatured hemoglobin) and bite cells Positive Prussian blue staining (detects hemosiderin) G6PD levels are usually paradoxically normal during hemolytic episode Notes : Patients are less susceptible to malaria Associated With : Episodic hemolysis from fava beans , oxidant drugs (esp

Consider transferring remaining peptide to fresh containers or using parafilm as supplemental sealing

10.1111/j.1365-2125.1977.tb00816.x 158 HollenbergN

505 YAP can assume various oxidized states depending on the intensity and duration of oxidative stress

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Published studies further suggest that decreased spinules are associated with impaired synaptic plasticity and intellectual disability, while increased spinules are linked to hyperexcitability and neurodegenerative diseases