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Selenium (Se) is an essential micronutrient that occurs predominantly as selenomethionine (SeMet), whereas vitamin E (or a-tocopherol) is a fat-soluble physiological antioxidant, both of which are required for normal health [1719]

In HF, reduced effective circulating blood volume triggers renal hypoperfusion, while central sympathetic overactivation forms a positive feedback loop, leading to sustained RAAS activation

This may contribute to COVID-19 critical illness as overactive ADAM17 can lower the ACE-2 function by generating inactive sACE-2

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