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The study authors found that intravenous injection of 42mg to 1260mg of TB4 was safe in healthy adults, with no dose limiting toxicities or serious adverse events reported [26]

Interestingly, the transcription factor c-Myc (involved in tumorigenesis in several cancers) can both promote proline (and also serine [101]) synthesis and inhibit proline breakdown [102], contributing to the protumor effects of proline

Exosome therapy offers several theranostics potentials in experimental studies, but there are still several practical issues that impede their clinical translation

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similar liposomal entrapment is applied to the nucleic acid-based drugs, with additional enrichment of nucleic acid entrapment by addition of a cationic derivative of cholesterol (DC-Choi) to the liposomes, as detailed in Gao and Huang, 1991, Biochem Biophys Res Commun