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J Appl Microbiol 105:529539

Nat Rev Urol 22 , 609631 (2025)

doi: 10.1007/s10555-023-10101-6, 5

The study found that triglycerides cross the blood-brain barrier and can induce leptin resistance.[ref open access] Theoretically, it makes sense that high triglycerides would block the leptin signal in times of starvation, driving people to need more food

The link between Kbhb of histones and hepatocellular carcinoma was also identified, and MTA2 interacts with HDAC2/CHD4 and represses BDH1 via R-loop transcription, leading to the accumulation of BHB and an increase in H3K9bhb, resulting in a cascade effect that promotes HCC formation and progression

Epithelial Atg5 deficiency intensifies caspase-11 activation, fueling extracellular mtDNA release to activate CGAS-STING-NLRP3 axis in macrophages during Pseudomonas infection