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1 Introduction Mitochondria are the primary organelles responsible for energy production ( Skeletal muscle relies on mitochondria to generate ATP through OXPHOS, providing energy for muscle contraction and sustained activity ( When mitochondrial OXPHOS function is impaired, it cannot meet cellular energy demands, leading to metabolic disorders and a range of diseases ( Mutations in either the nDNA or mtDNA genomes within mitochondria can disrupt ETC complexes

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[DOI] [PMC free article] [PubMed] [Google Scholar] 137.Balasubramanian I., Faheem A., Padhy S.K., Menon V