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Evans et al., British Journal of Nutrition (1982) Glutathione is the body's primary intracellular antioxidant, critical for phase II liver detoxification and for recycling vitamins C and E

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Notably, in allotransplant rejection, antigen recognition occurs through APCs processing and presenting alloantigen to host cells and the direct recognition of allogeneic MHC molecules on transplanted cells

A 2023 study published in Nature Metabolism found that vitamin B12 plays a pivotal role in one-carbon metabolism and cellular processes at the mitochondrial level, with B12 availability influencing how efficiently cells carry out energy-related reprogramming

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these glutathione molecules can then function again as antioxidants, scavenging reactive oxygen species from the cell